SNAP, Crackle, WebWindows!

We elaborate the SNAP---Scalable (ATM) Network and (PC) Platforms---view of computing in the year 2000. The World Wide Web will continue its rapid evolution, and in the future, applications will not be written for Windows NT/95 or UNIX, but rather for WebWindows with interfaces defined by the standards of Web servers and clients. This universal environment will support WebTop productivity tools, such as WebWord, WebLotus123, and WebNotes built in modular dynamic fashion, and undermining the business model for large software companies. We define a layered WebWindows software architecture in which applications are built on top of multi-use services. We discuss examples including business enterprise systems (IntraNets), health care, financial services and education. HPCC is implicit throughout this discussion for there is no larger parallel system than the World Wide metacomputer. We suggest building the MPP programming environment in terms of pervasive sustainable WebWindows technologies. In particular, WebFlow will support naturally dataflow integrating data and compute intensive applications on distributed heterogeneous systems

Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma

The pathophysiology of allergic asthma is driven by T-helper 2 (Th2) immune responses following aeroallergen inhalation. The mechanisms that initiate, potentiate and regulate airways allergy are incompletely characterized. We have previously shown that Hedgehog (Hh) signaling to T-cells, via downstream Gli transcription factors, enhances T-cell conversion to a Th2 phenotype. Here, we show for the first time that Gli-dependent transcription is activated in T-cells in vivo during murine allergic airways disease (AAD) a model for the immunopathology of asthma; and that genetic repression of Gli signaling in Tcells decreases the differentiation and/or recruitment of Th2 cells to the lung. We report that T-cells are not the only cells capable of expressing activated Gli during AAD. A substantial proportion of eosinophils and lung epithelial cells, both central mediators of the immunopathology of asthma, are also able to undergo Hh/Gli signaling. Finally, we show that Shh increases Il4 expression in eosinophils. We therefore propose that Hh signaling during AAD is complex, involving multiple cell types, signaling in an auto- or paracrine fashion. Improved understanding of the role of this major morphogenetic pathway in asthma may give rise to new drug targets for this chronic condition

Java for parallel computing and as a general language for scientific and engineering simulation and modeling

We discuss the role of Java and Web technologies for general simulation. We classify the classes of concurrency typical in problems and analyze separately the role of Java in user interfaces, coarse grain software integration, and detailed computational kernels. We conclude that Java could become a major language for computational science, as it potentially offers good performance, excellent user interfaces, and the advantages of object-oriented structure

Numerical Implementation of lepton-nucleus interactions and its effect on neutrino oscillation analysis

We discuss the implementation of the nuclear model based on realistic nuclear spectral functions in the GENIE neutrino interaction generator. Besides improving on the Fermi gas description of the nuclear ground state, our scheme involves a new prescription for $Q^2$ selection, meant to efficiently enforce energy momentum conservation. The results of our simulations, validated through comparison to electron scattering data, have been obtained for a variety of target nuclei, ranging from carbon to argon, and cover the kinematical region in which quasi elastic scattering is the dominant reaction mechanism. We also analyse the influence of the adopted nuclear model on the determination of neutrino oscillation parameters.Comment: 19 pages, 35 figures, version accepted by Phys. Rev.

Exploration of the InfoMall Concept Building on the Electronic InfoMall

This document describes: the InfoMall concept; how it is employed by the Northeast Parallel Architectures center (NPAC) as a technology transfer program, how it could be used by Rome Laboratory and by the United States Air Force Materiel Command (US AFMC). A description of the “Electronic InfoMall” system built on the World Wide Web as a pilot project for Rome Laboratory is also given as well as some experiences building WWW systems for academic, commerce and industry. It should be emphasized that this document is primarily a description of the potential uses of the InfoMall concept and the human interactive processes involved in InfoMall and is not primarily about the HPCC technologies that make the InfoMall process work. These technologies are well described elsewhere although we summarize their main features in this document

THE VOLUME OPERATOR IN DISCRETIZED QUANTUM GRAVITY

We investigate the spectral properties of the volume operator in quantum gravity in the framework of a previously introduced lattice discretization. The presence of a well-defined scalar product in this approach permits us to make definite statements about the hermiticity of quantum operators. We find that the spectrum of the volume operator is discrete, but that the nature of its eigenstates differs from that found in an earlier continuum treatment.Comment: 15 pages, TeX, 3 figures (postscript, compressed and uu-encoded), May 9

Exploration of Emerging HPCN Technologies for Web-Based Distributed Computing

The surge in the popularity of the World Wide Web (WWW) has corresponded to a decreasing market for specialised high performance computers. This paper discusses how, by making use of technology developed from the broader end of the computing pyramid, much of the past decade\u27s work in distributed computing can be realised in the context of the larger WWW market. Not only do these new technologies offer fresh possibilities, but their pace of development is unlikely to be matched by the traditional high performance research community. A motivating application, discussions of the pertinent emerging technologies, and NPAC\u27s investigations of them, will be presented

Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity

Lactoferrin (Lf), the major iron-binding component of milk, also a major constituent of the specific granules of neutrophils involved in antimicrobial activity and a glycoprotein thought to play a role in regulatory functions in the hematopoietic system as well as other physiologic activities, is shown to occur in three isoforms. One, Lf-alpha, binds iron; the other two, Lf-beta and Lf-gamma, express potent RNase activity, but do not bind iron. The three isoforms are very similar or identical in Mr, pI, partial proteolytic peptide patterns, NH2-terminal amino acid sequence, and reactivity with mAbs and polyclonal antisera against the RNase and Lf, respectively. The finding of structurally similar but enzymatically distinct forms of Lf may be related to the diverse functions of the molecule

Building Distributed Systems for the Pragmatic Object Web

We review the growing power and capability of commodity computing and communication technologies largely driven by commercial distributed information systems. These systems are built from CORBA, Microsoft\u27s COM, JavaBeans, and rapidly advancing Web approaches. One can abstract these to a three-tier model with largely independent clients connected to a distributed network of servers. The latter host various services including object and relational databases and of course parallel and sequential computing. High performance can be obtained by combining concurrency at the middle server tier with optimized parallel back end services. The resultant system combines the needed performance for large-scale HPCC applications with the rich functionality of commodity systems. Further the architecture with distinct interface, server and specialized service implementation layers, naturally allows advances in each area to be easily incorporated. We illustrate how performance can be obtained within a commodity architecture and we propose a middleware integration approach based on JWORB (Java Web Object Broker) multi-protocol server technology. We illustrate our approach on a set of prototype applications in areas such as collaborative systems, support of multidisciplinary interactions, WebFlow based visual metacomputing, WebFlow over Globus, Quantum Monte Carlo and distributed interactive simulations

Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease